Dr. med. Dipl. Psych. Elisabeth Petrasch-Parwez

Telefon: +49 (0)234 32 25008
Fax: +49 (0)234 32 14655
Raum: MA 6 / 45
Email: Elisabeth.Petrasch-Parwez@ruhr-uni-bochum.de
Sprechzeiten: nach Vereinbarung

Curriculum vitae

1979 Diplom in Psychologie, Fakultät für Psychologie, RUB
1984-1985 Praktisches Jahr im Augusta KHK, Bochum und Harvard Medical School, Boston, USA
1985 Staatsexamen in Humanmedizin, Gesamthochschule Essen, Approbation
1986 Promotion Dr. med., Medizinische Fakultät, RUB

Beruflicher Werdegang

1980-1981 Wissenschaftl. Hilfskraft bei Prof. Delius, Biologische Psychologie, Fakultät für Psychologie, RUB
1982-1984
1985-1988
Wissenschaftl. Mitarbeiterin bei Prof. Andres, Abt. Neuroanatomie, Medizinische Fakultät, RUB
1989-Heute Akademische Oberrätin bei Prof. Andres, Prof. Dermietzel, Prof. Förster, Abt. Neuroanatomie und Molekulare Hirnforschung, Medizinische Fakultät, RUB

Forschungsinteressen

Neurodegenerative Erkrankungen wie Huntington, Parkinson, Alzheimer und spinozerebelläre Ataxien sind progredient verlaufende Leiden, die durch einen fortschreitenden Verlust von Nervenzellen charakterisiert sind. Die einzelnen Krankheitsformen zeigen charakteristische Degenerationsmuster im Gehirn, die individuelle Ausprägung der Atrophien und Zelluntergänge ist jedoch enorm variabel. Auch die pathologischen Proteinaggregate, die bei neurodegenerativen Leiden krankheitsspezifisch im Gehirn beobachtet werden, zeigen eine Vorzugslokalisationen mit unterschiedlicher Ausprägung. Die genaue Pathogenese der Zelluntergänge und Aggregateinlagerungen ist noch ungeklärt. Im Vordergrund unserer Untersuchungen steht die Identifizierung Krankheits-spezifischer Neurodegenerationen und die Lokalisation und Struktur pathologischer Proteine in post-mortem Gehirnen von betroffenen Patienten und in Gehirnen von entsprechenden transgenen Tiermodellen.



Methodenschwerpunkte

Klassische Transmissionselektronenmikroskopie (Gewebe, Zellkultur, Zellsuspensionen)
Pre- und Postembedding Immunhistochemie für Licht- und Elektronenmikroskopie
Konfokale Immunfluoreszenzmikroskopie


Publikationen (ab 2000)

Van Well EM, Bader V, Patra M, Sánchez-Vicente A, Meschede J, Furthmann N, Schnack C, Blusch A, Longworth J, Petrasch-Parwez E, Mori K, Arzberger T, Trümbach D, Angersbach L, Showkat C, Sehr DA, Berlemann LA, Goldmann P, Clement AM, Behl C, Woerner AC,Saft C, Wurst W, Haass C, Ellrichmann G, Gold R, Dittmar G, Hipp MS, Hartl FU, Tatzelt J, Winklhofer KF. A protein quality control pathway regulated by linear ubiquitination. Embo J 2019 Mar 18

Schreiber S, Petrasch-Parwez E, Porrmann-Kelterbaum E, Förster E, Epplen JT, Gerding WM. Neurodegeneration in the olfactory bulb and olfactory deficits in the Ccdc66 -/- mouse model for retinal degeneration. IBRO Rep 2018, 5:43-53

Kastner S, Thiemann IJ, Dekomien G, Petrasch-Parwez E, Schreiber S, Akkad DA, Gerding WM, Hoffjan S, Günes S, Günes S, Bagci H, Epplen JT. Exome Sequencing Reveals AGBL5 as Novel Candidate Gene and Additional Variants for Retinitis Pigmentosa in Five Turkish Families. Invest Ophthalmol Vis Sci 2015 56:8045-53

Stemmler S, Parwez Q, Petrasch-Parwez E, Epplen JT, Hoffjan S. Asscociation of variation in the LAMA3 gene, encoding the alpha-chain of laminin 5, with atopic dermatitis in a German case-control cohort. BMC Dermatol 2014,14:1471-5945

Neitz A, Mergia E, Imbrosci B, Petrasch-Parwez E, Eysel UT, Koesling D, Mittmann T. Postsynaptic NO/cGMP Increases NMDA Receptor Currents via Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels in the Hippocampus. Cereb Cortex 2014, 7:1923-36

Kropatsch R, Dekomien G, Akkad DA, Gerding WM, Petrasch-Parwez E, Young ND, Altmüller J, Nürnberg P, Gasser RB, Epplen JT. SOX9 dublication linked to intersex in deer. PLoS One 2013, 8:e73734

Ebel P, Dorp KV, Petrasch-Parwez E, Zlomuzica A, Kinugawa K, Mariani J, Minich D, Ginkel C, Welcker J, Degen J, Eckhardt M, Dere E, Doermann P, Willecke K. Inactivation of ceramide synthase 6 in mice results in an altered sphingolipid metabolism and behavioral abnormalities.J Biol Chem. 2013 (Epub ahead of print)

Kelp A, Koeppen AH, Petrasch-Parwez E, Calaminus C, Bauer C, Portal E, Yu-Taeger L, Pichler B, Bauer P, Riess O, Nguyen HP. A novel transgenic rat model for spinocerebellar ataxia type 17 recapitulates neuropathological changes and supplies in vivo imaging biomarkers. J Neurosci. 2013 33:9068-81

Kropatsch R, Dekomien Gn, Akkad DA, Gerding WM, Petrasch-Parwez E, Young ND, Altmüller J, Nürnberg P, Gasser R, Epplen JT. SOX9 duplication linked to intersex in deer. PLos One 2013, accepted

Neitz A, Mergia E, Imbrosci B, Petrasch-Parwez E, Eysel UT, Koesling D, Mittmann T.
Postsynaptic NO/cGMP Increases NMDA Receptor Currents via Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels in the Hippocampus. Cereb Cortex 2013 Feb 28. [Epub ahead of print]

Prochnow N, Abdulazim A, Kurtenbach S, Wildförster V, Dvoriantchikova G, Hanske J, Petrasch-Parwez E, Shestopalov VI, Dermietzel R, Manahan-Vaughan D, Zoidl G. Pannexin1 stabilizes synaptic plasticity and is needed for learning. PLoS One 2012,7(12):e51767

Yu-Taeger L, Petrasch-Parwez E, Osmand A, Redensek A, Metzger S, Clemens, L Park L, Howland D, Calaminus D, Gu X, Pichler B, Yang XW, Riess O, Nguyen HP. A novel BACHD transgenic rat ex-hibits characteristic neuropathological features of Huntington disease. J Neurosci 2012, 32:15426-38

Petrasch-Parwez E, Habbes H-W, Löbbecke-Schumacher M, Saft C, Niescery J. The ventral striato-pallidum and extended amygdala in Huntington Disease, In: The Amygdala - a discrete multitasking manager (ed. Ferry B), 2012, Chapter 16, InTech

Nuber S, Petrasch-Parwez E, Arias-Carrión O, Koch L, Kohl Z, Schneider J, Calaminus C, Dermietzel R, Samarina A, Boy J, Huu P. Nguyena HP, Teismann P, Velavan TP, Philipp J. Kahle PJ, von Hörsteni S, Fendt M, Krüger R. Riess O. Olfactory neuron-specific expression of A30P alpha-synuclein exacerbates dopamine deficiency and hyperactivity in a novel conditional model of early Parkinson's disease stages. Neurobiol Dis 2011, 44:192-204

Brüne M, Schöbel A, Karau R, Faustmann PM, Dermietzel R, Juckel G, Petrasch-Parwez E. Neuroanatomical Correlates of Suicide in Psychosis: The Possible Role of von Economo Neurons. PLoS ONE 2011; 6(6)e20936

Gerding WM, Schreiber S, Schulte-Middelmann T, de Castro Marques A, Atorf J, Akkad DA, Dekomien G, Kremers J, Dermietzel R, Gal A, Rülicke T, Ibrahim S, Epplen JT, Petrasch-Parwez E. Ccdc66 null mutation causes retinal degeneration and dysfunction. Hum Mol Genet 2011, 15:3620-31

Ellrichmann G, Petrasch-Parwez E, Lee DH, Reick C, Arning L, Saft C, Gold R, Linker RA. Efficacy of fumaric acid esters in the R6/2 and YAC128 models of Huntington's disease. PLoS One 2011, 6(1):e16172

Benali A, Trippe J, Weiler E, Mix A, Petrasch-Parwez E, Girzalsky W, Eysel UT, Erdmann R, Funke K. Theta-Burst Transcranial Magnetic Stimulation Alters Cortical Inhibition. J Neurosci 2011, 31:1193-203.

Haghikia A, Missol-Kolka E, Tsikas D, Venturini L, Brundiers S, Castoldi M, Muckenthaler MU, Eder M, Stapel B, Thum T, Haghikia A, Petrasch-Parwez E, Drexler H, Hilfiker-Kleiner D, Scherr M. Signal transducer and activator of transcription 3-mediated regulation of miR-199a-5p links cardiomyocyte and endothelial cell function in the heart: a key role for ubiquitin-conjugating enzymes. Eur Heart J 2011, 10:1287-97

Kropatsch R, Petrasch-Parwez E, Seelow D, Schlichting A, Gerding WM, Akkad DA, Epplen JT, Dekomien G. Generalized progressive retinal atrophy in the Irish Glen of Imaal Terrier is associated with a deletion in the ADAM9 gene. Mol Cell Probes 2010, 6:357-63

Harazin M, Parwez Q, Petrasch-Parwez E, Epplen JT, Arinir U, Hoffjan S, Stemmler S. Variation in the COL29A1 gene in German patients with atopic dermatitis, asthma and chronic obstructive pulmonary disease. J Dermatol 2010, 37:740-2

Seidel K, Schöls L, Nuber S, Petrasch-Parwez E, Gierga K, Wszolek Z, Dickson D, Gai WP, Bornemann A, Riess O, Rami A, Den Dunnen WF, Deller T, Rüb U, Krüger R. First appraisal of brain pathology owing to A30P mutant alpha-synuclein. Ann Neurol 2010, 67:684-9

Brüne M, Schöbel A, Karau R, Benali A, Faustmann PM, Juckel G, Petrasch-Parwez E. Von Economo neuron density in the anterior cingulate cortex is reduced in early onset schizophrenia. Acta Neuropathol 2010, 119:771-8

Dekomien G, Vollrath C, Petrasch-Parwez E, Boevé MH, Akkad DA, Gerding WM, Epplen JT. Progressive retinal atrophy in Schapendoes dogs: mutation of the newly identified CCDC66 gene.
Neurogenetics 2010, 2:163-74

Stang A, Petrasch-Parwez E, Brandt S, Dermietzel R, Meyer HE, Stühler K, Liffers ST, Uberla K, Grunwald T. Unintended spread of a biosafety level 2 recombinant retrovirus. Retrovirology 2009;6:86

Stemmler S, Nothnagel M, Parwez Q, Petrasch-Parwez E, Epplen JT, Hoffjan S. Variation in genes of the epidermal differentiation complex in German atopic dermatitis patients. Int J Immunogenet 2009, 36:217-22

Hoffjan S, Beygo J, Akkad DA, Parwez Q, Petrasch-Parwez E, Epplen JT. Analysis of variation in the IL7RA and IL2RA genes in atopic dermatitis. J Dermatol Sci 2009, 55:138-40
Akkad DA, Hoffjan S, Petrasch-Parwez E, Beygo J, Gold R, Epplen JT. Variation in the IL7RA and IL2RA genes in German multiple sclerosis patients. J Autoimmun 2009, 32:110-5

Gierga K, Schelhaas HJ, Brunt ER, Seidel K, Scherzed W, Egensperger R, de Vos RA, den Dunnen W, Ippel PF, Petrasch-Parwez E, Deller T, Schöls L, Rüb U. Spinocerebellar ataxia type 6 (SCA6): neurodegeneration goes beyond the known brain predilection sites. Neuropathol Appl Neurobiol 2009, 35:515-27

Hoffjan S, Parwez Q, Petrasch-Parwez E, Stemmler S. Variation in the BDNF and NGFB genes in German atopic dermatitis patients. Mol Cell Probes 2009, 23:35-8

Beygo J, Parwez Q, Petrasch-Parwez E, Epplen JT, Hoffjan S. No evidence of an association between polymorphisms in the IRAK-M gene and atopic dermatitis in a German cohort. Mol Cell Probes 2009, 23:16-9

Nuber S, Petrasch-Parwez E, Winner B, Winkler J, von Hörsten S, Schmidt T, Boy J, Kuhn M, Nguyen HP, Teismann P, Schulz JB, Neumann M, Pichler BJ, Reischl G, Holzmann C, Schmitt I, Bornemann A, Kuhn W, Zimmermann F, Servadio A, Riess O. Neurodegeneration and motor dysfunction in a conditional model of Parkinson's disease. J Neurosci 2008, 28:2471-84

Zheng-Fischhöfer Q, Kibschull M, Schnichels M, Kretz M, Petrasch-Parwez E, Strotmann J, Reucher H, Lynn BD, Nagy JI, Lye SJ, Winterhager E, Willecke K. Characterization of connexin31.1-deficient mice reveals impaired placental development. Dev Biol 2007, 312:258-71

Macaluso F, Nothnagel M, Parwez Q, Petrasch-Parwez E, Bechara FG, Epplen JT, Hoffjan S. Polymorphisms in NACHT-LRR (NLR) genes in atopic dermatitis. Exp Dermatol 2007,16:692-8.

Zoidl G, Petrasch-Parwez E, Ray A, Meier C, Bunse S, Habbes HW, Dahl G, Dermietzel R. Localization of the pannexin1 protein at postsynaptic sites in the cerebral cortex and hippocampus. Neuroscience 2007, 146:9-16

Schimming TT, Parwez Q, Petrasch-Parwez E, Nothnagel M, Epplen JT, Hoffjan S. Association of toll-interacting protein gene polymorphisms with atopic dermatitis. BMC Dermatol 2007, 16;7:3

Lippmann T, Jonkisz A, Dobosz T, Petrasch-Parwez E, Epplen JT, Dekomien G. Haplotype-defined linkage region for gPRA in Schapendoes dogs. Mol Vis 2007, 13:174-80

Petrasch-Parwez E, Nguyen HP, Löbbecke-Schumacher M, Habbes HW, Wieczorek S, Riess O, Andres KH, Dermietzel R, Von Hörsten S. Cellular and subcellular localization of Huntingtin [corrected] aggregates in the brain of a rat transgenic for Huntington disease. J Comp Neurol 2007, 501:716-30

Stemmler S, Parwez Q, Petrasch-Parwez E, Epplen JT, Hoffjan S. Two common loss-of-function mutations within the filaggrin gene predispose for early onset of atopic dermatitis. J Invest Dermatol 2007,127:722-4.

Kutzleb C, Petrasch-Parwez E, Kilimann MW. Cellular and subcellular localization of paralemmin-1, a protein involved in cell shape control, in the rat brain, adrenal gland and kidney. Histochem Cell Biol. 2007,127:13-30

Hoffjan S, Parwez Q, Petrasch-Parwez E, Falkenstein D, Nothnagel M, Epplen JT. Association screen for atopic dermatitis candidate gene regions using microsatellite markers in pooled DNA samples. Int J Immunogenet 2006, 33:401-9.

Rüb U, Brunt ER, Petrasch-Parwez E, Schöls L, Theegarten D, Auburger G, Seidel K, Schultz C, Gierga K, Paulson H, van Broeckhoven C, Deller T, de Vos RA. Degeneration of ingestion-related brainstem nuclei in spinocerebellar ataxia type 2, 3, 6 and 7. Neuropathol Appl Neurobiol 2006, 32:635-49

Nguyen HP, Kobbe P, Rahne H, Wörpel T, Jäger B, Stephan M, Pabst R, Holzmann C, Riess O, Korr H, Kántor O, Petrasch-Parwez E, Wetzel R, Osmand A, von Hörsten S. Behavioral abnormalities precede neuropathological markers in rats transgenic for Huntington's disease. Hum Mol Genet 2006, 15:3177-94

Hu B, Petrasch-Parwez E, Laue MM, Kilimann MW.Molecular characterization and immunohisto-chemical localization of palmdelphin, a cytosolic isoform of the paralemmin protein family implicated in membrane dynamics. Eur J Cell Biol 2005, 84:853-66

Petrasch-Parwez E, Saft C, Schlichting A, Andrich J, Napirei M, Arning L, Wieczorek S, Dermietzel R, Epplen JT. Is the retina affected in Huntington disease? Acta Neuropathol. 2005, 110, 523-5

Striedinger K, Petrasch-Parwez E, Zoidl G, Napirei M, Meier C, Eysel UT, Dermietzel R. Loss of connexin36 increases retinal cell vulnerability to secondary cell loss. Eur J Neurosci 2005, 22:605-16

Petrasch-Parwez E, Habbes HW, Weickert S, Löbbecke-Schumacher M, Striedinger K, Wieczorek S, Dermietzel R, Epplen JT. Fine-structural analysis and connexin expression in the retina of a transgenic model of Huntington's disease. J Comp Neurol 2004, 479:181-97

Degen J, Meier C, Van Der Giessen RS, Söhl G, Petrasch-Parwez E, Urschel S, Dermietzel R, Schilling K, De Zeeuw CI, Willecke K. Expression pattern of lacZ reporter gene representing connexin36 in transgenic mice. J Comp Neurol 2004, 473:511-25

De Zeeuw CI, Chorev E, Devor A, Manor Y, Van Der Giessen RS, De Jeu MT, Hoogenraad CC, Bijman J, Ruigrok TJ, French P, Jaarsma D, Kistler WM, Meier C, Petrasch-Parwez E, Dermietzel R, Sohl G, Gueldenagel M, Willecke K, Yarom Y. Deformation of network connectivity in the inferior olive of connexin 36-deficient mice is compensated by morphological and electrophysiological changes at the single neuron level. J Neurosci 2003, 23:4700-11

Zoidl G, Meier C, Petrasch-Parwez E, Zoidl C, Habbes HW, Kremer M, Srinivas M, Spray DC, Dermietzel R. Evidence for a role of the N-terminal domain in subcellular localization of the neuronal connexin36 (Cx36). J Neurosci Res 2002, 69:448-65

Meier C, Petrasch-Parwez E, Habbes HW, Teubner B, Güldenagel M, Degen J, Söhl G, Willecke K, Dermietzel R.Immunohistochemical detection of the neuronal connexin36 in the mouse central nervous system in comparison to connexin36-deficient tissues. Histochem Cell Biol 2002, 117:461-71

Schmitz D, Schuchmann S, Fisahn A, Draguhn A, Buhl EH, Petrasch-Parwez E, Dermietzel R, Heinemann U, Traub RD. Axo-axonal coupling. a novel mechanism for ultrafast neuronal communication. Neuron 2001, 31:831-40

Teubner B, Degen J, Söhl G, Güldenagel M, Bukauskas FF, Trexler EB, Verselis VK, De Zeeuw CI, Lee CG, Kozak CA, Petrasch-Parwez E, Dermietzel R, Willecke K. Functional expression of the murine connexin 36 gene coding for a neuron-specific gap junctional protein. J Membr Biol 2000 176:249-62

Wang X, Herberg FW, Laue MM, Wullner C, Hu B, Petrasch-Parwez E, Kilimann MW. Neurobeachin: A protein kinase A-anchoring, beige/Chediak-higashi protein homolog implicated in neuronal membrane traffic. J Neurosci 2000, 20:8551-65

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